Differences in SMN1 allele frequencies among ethnic groups within North America

Differences in SMN1 allele frequencies among ethnic groups within North America

BACKGROUND Spinal muscular atrophy (SMA) is the most common inherited lethal disease of children. Various genetic deletions involving the bi-allelic loss of SMN1 exon 7 are reported to account for 94% of affected individuals. Published literature places the carrier frequency for SMN1 mutations between 1 in 25 and 1 in 50 in the general population. Although SMA is considered to be a pan-ethnic d...

The Comparative Study of Obesity Differences for Schoolchildren between Turkman and Sisstanish Ethnic Groups in the North of Iran

Abstract Background and purpose: Overweight and obesity are the health problem in adolescents and the main purpose of this study was to evaluate this problem and some socio-demographicrelated factors among two ethnic groups in Iranian northern primary school children in 2010. Materials and Methods: This was a descriptive and cross-sectional study that performed on 4165 students (Turkman = 2852a...

Inequality within ethnic groups

Differences in rate of uptake of immunisation among ethnic groups.

In the Bradford health district ethnic origin is associated with appreciable differences in morbidity and mortality. In view of these differences a study was undertaken to determine whether there were differences among the ethnic groups in utilisation of the National Health Service, as reflected in the rate of uptake of immunisation, which is offered to all children. Significant differences wer...

Ethnic differences in the distribution of interleukin-6 polymorphisms among three Brazilian ethnic groups.

Polymorphisms in the interleukin-6 promoter region have been associated with diseases. In this study we investigated the -634G/C and -174G/C IL-6 promoter polymorphisms in three Brazilian ethnic groups. We verified that the allele frequencies of the two polymorphisms and haplotype frequencies varied significantly between the populations.